Challenges & Countermeasures in Optical Noninvasive Blood Glucose Detection

The aim of this paper is to discuss important issues for design and development of noninvasive blood glucometer. Noninvasive blood glucose monitoring could improve life quality of diabetes patients, enabling a better regulation of hyper and hypoglycemia conditions. Research to develop noninvasive glucose sensing technology is driven by the promise to provide in vivo glucose concentrations without pain, cost, and inconvenience of test strip meters. The optical approaches have brought exciting advances to this field. Till date several methods have been proposed for non invasive measurement of glucose level, present paper discusses their principle advantages and limitations. Most of these criteria center on selectivity of the analytical measurement, signal to noise ratio (SNR) of the instrumentation, physical and chemical properties of the measurement site, and robustness of the calibration model.